While the WTO agreements came into force on 1 January 1995, the TRIPS agreement granted WTO members certain transitional periods before they were required to implement all their provisions. Members of developed countries were given one year to ensure that their laws and practices complied with the TRIPS Agreement. Members of developing countries and, under certain conditions, the transitional economy enjoyed a five-year period until the year 2000. The least developed countries were first 11 years old, until 2006 – now they are generally extended until July 1, 2021. Since the TRIPS agreement came into force, it has been criticized by developing countries, scientists and non-governmental organizations. While some of this criticism is generally opposed to the WTO, many proponents of trade liberalization also view TRIPS policy as a bad policy. The effects of the concentration of WEALTH of TRIPS (money from people in developing countries for copyright and patent holders in industrialized countries) and the imposition of artificial shortages on citizens of countries that would otherwise have had weaker intellectual property laws are common bases for such criticisms. Other critics have focused on the inability of trips trips to accelerate the flow of investment and technology to low-income countries, a benefit that WTO members achieved prior to the creation of the agreement. The World Bank`s statements indicate that TRIPS have clearly not accelerated investment in low-income countries, whereas they may have done so for middle-income countries.  As part of TRIPS, long periods of patent validity were examined to determine the excessive slowdown in generic drug entry and competition. In particular, the illegality of preclinical testing or the presentation of samples to be authorized until a patent expires have been accused of encouraging the growth of certain multinationals and not producers in developing countries. The TRIPS agreement is the only international agreement that details respect for intellectual property rights, including rules on evidence, interim measures, compensation measures and other sanctions. It states that courts must, under certain conditions, have the right to order the disposal or destruction of property that violates intellectual property rights.
Intentional infringement or commercial-scale copyright piracy must be punishable. Governments must also ensure that IP rights holders are provided with assistance from customs authorities to prevent the importation of counterfeit and illegally manufactured goods. The 2002 Doha Declaration confirmed that the TRIPS agreement should not prevent members from taking the necessary steps to protect public health. Despite this recognition, less developed countries have argued that flexible TRIPS provisions, such as mandatory licensing, are almost impossible to obtain. The least developed countries, in particular, have made their young domestic manufacturing and technological industries proof of the infallible policy. The Agreement on Trade-Related Intellectual Property Rights (TRIPS) is an agreement of international law between all World Trade Organization (WTO) member states. It sets minimum standards for the regulation of different forms of intellectual property by national governments, as is the case for nationals of other WTO member states.  The TRIPS agreement was negotiated at the end of the Uruguay Round of the General Agreement on Tariffs and Trade (GATT) between 1989 and 1990 and is managed by the WTO.
The Agreement on Trade-Related Intellectual Property Rights (“TRIPS” is the first WTO agreement that requires members to establish relatively detailed material standards in their national legal systems and to compel them to define excessive measures and procedures